SCIENTIFIC GROUNDS

Bella Aurora Research

An average of 2% of the world’s population is affected by white patches and there has been no effective cosmetic treatments to date. Bella Aurora has succeeded in blocking their cause and helping to repigment the skin.

A discovery about hypopigmentation: MIA protein blocking

Bella Aurora Labs, in collaboration with the dermatologist specialised in the study of vitiligo, Dr. Matteo Bordignon, have discovered exactly what triggers hypopigmentation and the formula for treating it. The result: a totally new mechanism of action which blocks the protein responsible for white patches and restores pigment to the skin.

MIA protein, a new cause

In 2013, Dr. Matteo Bordignon published the discovery of a new molecule responsible for white patches: MIA protein. Produced abnormally by the melanocytes (the cells that pigment the skin), MIA protein1 causes them to become detached from the basal membrane and to migrate to the superficial layers of the skin where they are swept away with other epidermal cells, causing white patches. According to this hypothesis, these melanocytes are not destroyed, but are simply scrubbed away 1. In 2020, an experimental model finally confirmed this finding2.

1. Melanoctyes secrete MIA protein and trigger the formation of white patches

2. MIA protein detaches the melanocytes from the basal layer

3. The melanocytes come loose and depigmented patches appear

An innovative cosmetic treatment

The Repigma12 peptide, the solution that blocks MIA protein.

Repigment12, with its own patent and exclusive formulation developed by Bella Aurora, is the first cosmetic treatment in the world that blocks the effects of MIA protein. Not only stops white patches from developing, it repigments them. The key lies in Repigma12 peptide, a sequence of 12 amino acids that penetrates through the skin to the basal layer and adheres to MIA protein, preventing it from activating and detaching the melanoctyes.

Once the MIA protein is blocked, the melanoctyes stabilise and, through phototherapy (with sunlight and/or artificial UV), depigmented areas can be fully repigmented.

Communications and conferences

References

1. Bordignon M, Castellani C, Fedrigo M, Thiene G, Peserico A, Alaibac M, et al. Role of alpha5beta1 integrin and MIA (melanoma inhibitory activity) in the pathogenesis of vitiligo. J Dermatol Sci. 2013 Aug;71(2):142-5.

2. Bordignon M, Luisetto R, Valente ML, Fedrigo M, Castellani C, Angelini A, et al. Melanoma Inhibitory Activity (MIA) Is Able to Induce Vitiligo-Like Depigmentation in an in vivo Mouse Model by Direct Injection in the Tail. Front Med (Lausanne). 2020 Aug 21;7:430.

“Developing Repigment with Bella Aurora has been incredibly exciting: at last we’ve come up with a formula that repigments the skin and restores its natural colour.”

Dr. Matteo Bordignon & Sergi Hernandez, Fundamental Research Manager at Bella Aurora

Innovation

Repigment, an innovative cosmetic treatment

The new solution for treating white patches consists of Repigment12 cream with Repigma12 peptide to block the MIA protein, and RepigmentSun capsules, a food supplement that prepares the skin for exposure to the sun or UV radiation sessions.

We recommend applying the cream twice daily to the affected areas and taking one capsule per day. Exposure to natural sunlight is necessary (avoiding burns) or UVA or UVB sessions in booths twice weekly, to encourage the activity, reproduction and mobility of the melanocytes and total repigment the skin. We recommend that the process be supervised by a healthcare professional.

Find all the information you need about using Repigment.

White patches are repigmented in 82% of patients

The effectiveness of product to treat hypopigmenation has been demonstrated in clinical studies with 15 patients, with an effective response in 82% of cases.

Evolution of the skin in patients treated with Repigment and adjuvant phototherapy.
Photos with Wood light taken at Dr. Matteo Bordignon's dermatology clinic.

Effective after 3 months

Extremely well tolerated

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Answers to all your questions about Repigment and hypopigmentation

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